Uterine perforation during intracavitary brachytherapy for carcinoma of the cervix.

To cite: Prabhakar GS, Revannasiddaiah S, Susheela SP, et al. BMJ Case Reports Published online: 13 December 2012 doi:10.1136/bcr-2012007830 DESCRIPTION Following a seemingly straightforward procedure to place the necessary applicators (comprising the central tandem into the uterine cavity, and the right and the left ovoids into the lateral vaginal fornices), this patient of cervical-carcinoma, who was scheduled to receive intracavitary brachytherapy (ICBT) was taken up for CT scanning intended for dose-optimised three-dimensional conformal brachytherapy. Surprisingly, it was noted that the central tandem had pierced through the posterior wall of the uterus to enter the abdominal cavity (figures 1–3). The uterine body was visualised as anteflexed, even though a preprocedure clinical examination was not suggestive of the same. The applicators were removed, and the procedure was postponed. Successful radiotherapy for cervical carcinoma typically requires the integration of brachytherapy with external-beam radiotherapy. Brachytherapy allows adequate dosing of the uterus, upper-vagina, cervix and a small area of adjoining parametrium, while at the same time sparing the urinary bladder and rectum from excessive doses. ICBT is a timetested treatment for cervical carcinoma, wherein the accessible utero-cervical cavity is irradiated from-within by the placement of applicators to facilitate radioactive-source loading. With regard to applicator placement, even though ultrasound-guidance is known to reduce the risk of uterine perforations, it remains unadopted by a majority of clinicians. This report illustrates the potential benefit that could have been had with ultrasound-guidance. In the current era, the applicators are loaded with a computer-controlled iridium-192 source which delivers the radiation. After the placement of the tandem and ovoids, the dose-optimisation is usually done either with a traditional ‘x-ray simulation’ or with a ‘CT-simulation’. Though the x-ray simulation is simple and less-expensive, CT-simulation is Figure 1 Axial CT slice demonstrating the location of the uterine tandem (black arrow), the uterus (outlined in white) and a loop of small intestine (outlined in blue) which could have been exposed to radiation overdose if not for the discovery of the applicator malposition.